How the MYC Gene May Revolutionize Muscle Growth and Aging

The **MYC gene** has long been associated with cancer, but new research highlights its role in muscle adaptation to exercise. Typically, MYC levels increase after exercise, aiding in muscle growth. However, as we age, this response weakens, leading to decreased muscle recovery and growth. The study, spanning multiple institutions, examined the molecular changes in human muscles post-exercise and tested if pulses of MYC could independently stimulate muscle growth in mice. Results confirmed that MYC alone could increase muscle mass without physical exercise. Despite this promising discovery, MYC's broad gene regulation and potential to stimulate uncontrolled cell growth caution against its direct application due to cancer risks. Instead, researchers aim to harness MYC’s beneficial effects while mitigating its oncogenic potential. Notably, MYC is one of the Yamanaka factors known for cellular reprogramming, furthering interest in its role in muscle aging and adaptability. The study opens avenues for therapies that combat age-related muscle loss by targeting MYC's downstream effects without cancer risks.