Innovative Artificial Cilia System for Real-Time Airway Monitoring

**Xiaoguang Dong**, an assistant professor of mechanical engineering, leads a research team that has developed an advanced system of artificial cilia designed to monitor mucus conditions in human airways. This innovative technology promises to enhance the detection and diagnosis of infections and diseases such as **Cystic Fibrosis (CF)**, **Chronic Obstructive Pulmonary Diseases (COPD)**, and **lung cancer** by providing real-time data. Published in the November 4 issue of PNAS, the study highlights the importance of continuous monitoring of airway conditions, especially for patients with airway stents. While current methods rely heavily on imaging and inspections that carry radiation risks and lack real-time feedback, this new technology mimics the sensing abilities of biological cilia. It engages external magnetic fields to actuate magnetic artificial cilia, using a flexible strain-gauge for mucus viscosity and capacitance sensing for layer thickness. Tested within artificial and sheep tracheas, the system wirelessly transmits data to smartphones, paving the way for timely medical interventions and personalized care. The project, done in collaboration with Vanderbilt University Medical Center, also earned Dong a prestigious R21 Trailblazer Award from the NIH, encouraging further research at the intersection of life sciences and engineering.