Revolutionizing Genomics: A New Evolutionary Approach to Human Gene Functions

**A ground-breaking resource, the PAN-GO functionome, has been released by the Gene Ontology Consortium**, providing an **encyclopedia of human gene functions**. This resource is the first to integrate large-scale evolutionary modeling, utilizing genetic data from both humans and model organisms like mice and zebrafish. By tracking **the evolutionary history of thousands of genes**, scientists can fill in gaps where direct human gene data is unavailable. Compiled from reviews of over 175,000 scientific publications, it lists the known functions of **more than 20,000 protein-coding genes**. This resource, developed by a global team of 150 biologists, will allow researchers to better understand biological processes and their malfunctions in diseases like cancer. Although comprehensive, about **3,600 genes still lack experimental data**, highlighting areas for future research. Importantly, this resource is structured in a machine-readable format, enabling **AI-driven analysis** and ongoing updates from the research community.